Hopefully this will be an incentive to the manufacturers to bust out some engineering. I know that the hybrids are using Atkinson cycle (aka 5 stroke) engines, and Mazda did have a Miller cycle V6 engine for a while which was 13% more efficient than a conventional Otto cycle gas engine.
And Bruce Crower has built a six stroke engine that re-captures heat loss and runs without pumping coolant so theres no parasitic drag from a water pump:
http://www.autoweek.com/apps/pbcs.dl...THISWEEKSISSUE
I think whats holding us back in part is the use of the conventional gasoline fueled/otto cycle/piston engine model. I imagine the car of the future that does get 100mpg will probably have some new kind of engine thats very different from what we have now.