Plenty of street cars run meth injection - mine does. Now, if you mean methanol as the fuel source, that is not a legal fuel for the street.
E85 is sold from the pump - there is a station right by my house even. It is street legal pump fuel.
VP100 is not sold at the pump, as far as I know, but it is a street legal fuel also.
C16 is not street legal.
A street car must meet all safety laws, including seatbelts, DOT legal tires and fuel. Technically, it shouldn't be running nitrous (line can't be hooked up), but we all tend overlook that one. A street car must have tags and registration, and insurance.
It should also have a legal DOT windshield. That's about it.
There are no rules that say a street car has to have a specific engine, transmission, or heat or A/C, or even a full interior. Keep this simple.