The only real difference is the outer shell, they are basically the same underneath. With only a couple mechanical differences and the obvious difference of looks on the outside.
Which brings me to my point. Humans, whether male or female, are basically the same. There are only a couple of things that differentiate between the two and those that feel that they need to live as the other can easily do so nowadays. I say let them do what they want and if you don't like transgendered people just be polite and avoid them.