Not unless you're stringing bass. Acoustic/electric guitar strings are like razorwire when attempting to strangle someone and will lead to a crimson shower.
Try this trick that I learned in the Army; sneak up on your victim from behind with a bayonet (or any other short-handed blade) and wrap your free hand over their mouth. Human instinct will have them raise their arm(s) in a motion of self defense. When this is done, quickly thrust the knife up and into their now exposed armpit. There is a major artery here and severing it will cause a quick bleedout. The bonus of using this method is that by strike their armpit instead of slitting their throat, the sprayed blood is contained within their clothing and allows for a faster and more discrete cover-up.
