Quote Originally Posted by AnthonyF
No. Do not put anti-seize on your lugs. You'll get a false tq rating when tightening down the lugs. Hondas require 80 ft lbs.

-Ant.
I have always use Anti-sieze on all of my cars so the threads do not dry out. Please remember that if your tighten a dry thread it will give you a false reading as well.
My recommendation is to use a little bit to keep the threads from getting stuck.
Just my $0.02.