try running multiple different spyware checker programs like spydoctor, the microsoft one and the lavasoft one. Do them all in safe mode while your computer is NOT connected to the internet. Scan, reboot, scan, reboot etc... do it until it doesn't find anything else. When done run virus checker until it finds nothing, and maybe even run the spyware again once after that... Also find a defragment program...

Let me know how it works and if you have any questions...