yes, you absolutely want the tip over switch to work. you dont want the motor to continue running after you crash for several reason. If its on its side, its not getting oil to the pickup, creating oil pressure loss and damaging your engine. Also, if there is a fuel leak, it will cut it off before it becomes a bigger fire hazard with a hot exhaust.

if your talking about the sidestand switch, then I would also leave that on. You dont want to take off with your sidestand down and then try to make a left hander and dig in your stand and crash.