50 got beef with Fat Joe because Joe got with Ja Rule and dropped a verse in a song that dissed 50. From my understanding, Joe's verse wasn't a shot at 50. 50 wrote a track called Piggy Back which was a shot at everyone associating with Ja.

50 and Nas came around because he thought Nas was talking shit about him at a concert Nas was doing. 50 called Nas a traitor(I don't know why) and put him in the Piggy Back track because Nas allied himself with Irv Gotti and Ja. 50 is also jealous/mad because J-Lo had a remix of a song with Nas and 50 each. The Nas remix got more circulation and play than the 50 remix.

50's beef with Jada is another Ja Rule beef. Jada agreed to do a one time track with Ja and 50 didn't like that so he took a shot or two at him in the Piggy Back song, also.

50 is mad at Ja Rule because one of 50's grade school friends robbed Ja of his necklace. Later, 50 was supposedly stabbed by a member of Ja's crew. After that, Ja and Irv Gotti threw out the rumor that 50 was a snitch because 50 went and got a restraining order against them.

Later, QD.