Well, to truly tell you how it needs to be run, we'd need to know the brand and model of the amp and its specs, as well as the subwoofers themselves.

A quick version:
Connect the two speakers to one another parallel (positive to positive & negative to negative), then run the wire from one of the speakers to the amp. If it's a good mono, it should be able to run in the 2Ohm or 1Ohm load.

James E.