From a lubrication standpoint synthetics in general may be better in a high RPM or race engine setting, but have no real benefits for lubrication in a otherwise stock engine. There are negligible mpg savings as long as the weight is the same.

Also, synthetic and good fossil oils both suffer the same fate in a combustion engine: contamination from the combustion process. Meaning in the same amount of mileage they will be equally contaminated. This is why I always run plain mobil or castrol 5w30 for 5k miles in my vehicles with OEM filters.

I remember a several years back we had a Corolla customer come in to my previous work. Vehicle had 35k on the engine and 2 oil changes with AMSOIL. Spun bearing. Only one i'd ever seen on a low mileage engine.