hence why most high horsepower turbo cars melt down on 4th gear pulls or pull on the highway cause the EGTs go through the roof. at least from whati have seen. lots of long pulls can blow shit up and melt pistons QUICK.this is where detonation comes in, because it causes huge spikes in the force upon the internals. preignition/detonation causes the air/fuel to burn while the piston is still traveling upward being pushed by the rest of the engine, so it's kind of like the difference between running your car into a stopped semi truck at 30mph or hitting the same semi truck head on when they're coming at you at 60mph. the forces placed on the parts are multiplied, and then suddenly your nicely tuned engine becomes shrapnel. the counterpart to this is heat, because as pressure increases so does the temperature (why tune by the EGT gauge). extreme pressure causes extreme heat, which compounds the problem of bad tuning causing burned pistons/valves if you're lucky enough not to throw a rod through the block.
also, its a known fact the 350z motors have weak rods. yes you can get away with 10-12psi, for how long though? i mean, its possible, hell i have seen 450whp stock sleeves and rods in a honda motor, but if you are boosting ALL THE TIME EVERY DAY, it aint gonna last. not IMO